i got a new tv and i'm starting to build a home theater around it so i'm on the lookout for a universal remote. right now its just tv + cable box, but i'll be getting a receiver soon and either a dvd player or HTPC. i was looking mainly at the MX-600 + RF station, but then i saw that compusa has the harmony 659 on sale for about $50 less than what the mx-600 + RF station would be.

the RF isn't a huge deal for me since i probably wouldnt need to control anything from different rooms, but it'd be nice to have just from an ease of use stand point. is there any other major benefit to the mx-600 over the harmony 659 that would justify the extra $50?

Only the RF really. If you don't need RF, you could also consider the MX-500 (same as the 600 without the RF).