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What music do you listen to and how? What are you listening to now? What is your budget?

What I suggest you consider is having the room correctly designed so that whatever you get will sound its best. A decent investment in acoustics is worth more than most incremental hardware investments. See www.rivesaudio.com for ideas, suggestions and links.

For hardware, I would advise you to begin with a killer 2 channel system since you did not mention HT or surround in your posts. A biased suggestion is to consult www.stereophile.com for reviews and commentary. ;-)