Just upgraded from a 3250HD to 4250HDC and used the very same connections.

I noticed the sound a little bit different and TV has to be on a higher volume to get the same effect as before, also the overall TV sound is distorted, like listening to a center speaker or back-right speaker only in a 5.1 setup.

The connection with the problem is to the TV using a regular red/white cable.
TV is Toshiba 32HFX72, before it displayed the info on a channel with "STEREO" in the upper left corner, now it doesn't.
Another thing I've noticed is that if I unplug one of the cables, either white or red, I still get sound in both TV speakers...

I checked with SA user manual, searched the net and played with the box' settings yet couldn't find anything certain.

Thanks,
Ovidiu