I got the Simpsons game for PS3 last week.

When I inserted the disc, the game starts normall, but
there is absolutely no sound.

Both of my PS3 consoles(40GB and 80GB) play BD movies
and other PS3 games with sound. No problems there...
I have about 10 other PS3 games and 60 BD movies, all
play without any problems.

The no sound problem is only limited to just the Simpsons
games... :confused:

any help appreciated!

Have you tried seeing if DTS is checked in your sound setting in your xmb? If so, uncheck it.