I favor trying it. The sub in the corner will give you the most output. This may or may not give you the cleanest bass. Like the other poster said, give it a try.
Klipsch RF 7 based HT 7.4, Pioneer SC 35, Acurus 200 Five, Dayton 18 Ultimxa Dual Sub Cab(2), Dayton 18 Ultimax Large Vented Sub Cab (2), on Berhinger I Nuke DPS amps, Samsung BDP F 7500, Asus/My Book Live HPC 4 TB
Yaquin VK 2100 amp, McIntosh XR 5 speakers, Samsung BDP F 7500