Ported sub is the way to go for a large space and if you can only get one for now. In time the wife will get used to the room and a second sub may not be out of the question. That is what happened for me. Then I wanted a third and fourth sub and got kicked out of the family room, lol.
Klipsch RF 7 based HT 7.4, Pioneer SC 35, Acurus 200 Five, Dayton 18 Ultimxa Dual Sub Cab(2), Dayton 18 Ultimax Large Vented Sub Cab (2), on Berhinger I Nuke DPS amps, Aura Bass shakers, Samsung BDP F 7500, Asus/My Book Live HPC 4 TB
Yaquin VK 2100 amp, McIntosh XR 5 speakers, Samsung BDP F 7500