Try messing with the CPU settings. I tried dropping down the interceptions setting to zero but I still throw picks occasionally. Most of the time they are from throwing into coverage but I also feel the CBs and DBs in the game have amazing hands and would like to see more balls just knocked down. I've also been struggling with adjusting the penalties so they would be more realistic. I got some settings from Operation Sports forums and have been tweaking them for more realistic action.
PSN/XBOX Live: Destro75
BattleNet Tag: BaronessMD#1680
Gaming PC: i7 3770K OC 4.2Ghz, 16GB RAM, MSI 4G GTX 970