DTS Interactive (I thought it was called DTS Connect) will encode your audio into a DTS stream, so as long as your receiver will decode it, you should be fine. However, it's a lossy DTS stream. My experience with Dolby Digital Live was that the loss of quality due to compression was noticeable in many sources.
I'm not sure of the details of your setup, but if your receiver supports multichannel PCM over HDMI, I would strongly suggest investing in a video card or soundcard that can output multichannel PCM audio over HDMI. You wouldn't have any loss of quality this way.