I haven't auditioned nearly as many mains and subs as you have for sure, and even fewer in this room (just the PRO/SHO/PRO combo and these - along with the pair of THT LPs). My previous living room setups were B&W 60x series, and now HTD in-walls for living room and master bedroom (TV watching rooms essentially).
I plan to do some A/B tests between the SEOS LCRs and the PRO/SHO/PRO LCRs, maybe this weekend. Just sit them both on the floor, and then play a scene, swap banana plugs and MCACC memory settings, then replay the same scene; repeat until sick of it. Then maybe I can give a more accurate description than I can now.
My early impressions - the difference is noticeable, but somewhat subtle: a bit more kick in the crossover region (I ran the CHTs with the crossover at 100 Hz for best effect, I didn't notice any difference with the SEOS crossing over at 80 vs. 100, so left at 80 for now); vocals slightly less "boxy" (maybe due to more internal damping?); maybe slightly more detail / nuance - but that and other impressions could well be placebo until I actually do back to back listening.
Re: toe-in - I'm still experimenting, don't take the pictures as my final setup. In the past, I've toed in 45 degrees to cross in front of the LP, to good effect, but it wasn't a huge difference, so I'll try different amounts of toe in and see what I like. I made these coffins so deep that 45 degrees may not be possible anyway, we'll see.