Why don't you look into a HID prox/iclass type of card based system rather than the hybrid keys. If you want the high security of the medeco locks, you can stiill use medeco cylinders in the electronic locks. Then you can use any security access panel to control who has access and how the access is granted (by group, time, day, etc). If you want a key "shape" you can get prox tags that are shaped like keys as well. . .
It's a lot easier working with access control panels (like GE, Bosch, Kantech, Northern, etc) than the standalone kind. Several Access control boxes are controlled via http as well.