Okay... so here's my 2 cents...
But first, some context...
My setup... in a finished basement, 20 x 9 - two small windows, but the sun streams in during the morning. TV is situated on a short stand/table ~14inches high - there is a staircase behind the TV (which affects the sound from the TV)
Comcast HD (DVI to HDMI cable plus audio cables)
SD dvd/vcr combo (old school...I know, I know.. get with the program)
Bose Lifestyle 50 system (again, I know)
No game console...yet.
No BR player..I know, PS3 - combo BR player and console... prob is I think I want more XBOX based games (I prefer driving sims)..GT5 I know..but that is all OT...
So, the best I can get is 1080i out of Comcast and it still looks awesome. I'm coming from a Vizio 37 LCD in the same space so it's quite a step up in viewable area!
Typical viewing is mostly movies, science channel, and some sports - baseball and either F1 or Speed GT/ALMS races - btw, watched the home opener for the Red Sox (live near Boston) and during the ring ceremony - some of the super close-ups on these guys, I'm thinking, 'dude, decided not to shave this AM?'... talk about detail!
As far as settings... I'm all over the map... trying different things, tried the 61/65 series post 1499 - still not sure yet - there are SO many variables.
On the sound topic ... for the total experience you need a surround sound setup... with a screen this big (46) or bigger you miss out not having it. That said, if I'm just turning on the TV to watch some science channel show, I'm not going thru the whole thing to rev up the whole audio setup.
Out of the box, I agree, the sound was so so. I turned on the SRS TruSurround and cranked up the low frequencies in the EQ - that seemed to do the trick for me. But as I noted before, the speakers are firing down at a solid piece of furniture and bouncing off the back of the stair wall back towards me. Since your specific setup in terms of, on a wall, in a cabinet/surround, lots of furniture/carpet, size of room will all affect how the sound reaches you, my solution may not be sufficient for others.
I've seen a couple scenes 'break-up' or pixelate (if that's even a word) in the center of the TV while watching cable but I think that was the signal, not the TV as I've not noticed anything with the DVD player.
I'm watching Star Wars (the original on an SD DVD player, no upscaling - again.. out of date tech, I know....) and still looks excellent. Though I noticed in one of the tie-fighter scenes I could actually see the square mat from the animation that they did (lovin' the contrast ratio!).
Ok, haven't tested the wiselink stuff yet... off to give that a try and keep working my calibration.
Will try to post a couple pics of the setup later.