I have a Xbox Elite so I have HDMI, I prefer to use VGA, The picture was almost as detailed as HDMI 2/PC but felt like it had less lag. Also the colors appeared to be more vivid. This is just my opinion, I did not do any tests, all that really matters is that you like the results and I am extremely happy. I found a Microsoft VGA cable for $30 it allows you to hook up a fiber optic cable and also provides you with a left and right RCA cable for stereo. I use the fiber optic for my receiver, and the stereo for the TV. A nice feature about VGA is that it frees up an extra HDMI port. I run DirecTV, Apple TV, and Blu-Ray all independently to the TV, the big feature of this is it gives me audio at the TV.
I then use fiber optic from the DirecTV HDDVR, and the Apple TV and analog 7.1 for the Blu-Ray to hook up to my receiver for surround sound. I ran another fiber optic cable from my TV digital out to my receiver for over the air channels and PIP. This setup requires a lot of extra cables but gives you the ability to calibrate each source independently and allows you to be able to use surround sound or the TV speakers. My receiver is HDMI capable but the PQ was not as good as my current configuration, and I lost the ability to optimize settings for each source. All that is left is to program my Harmony 1000 remote and enjoy my system.