I have had this set since July of last year, and have been quietly following all the different settings and particular issues with this set. There is no doubt the picture quality and black levels are top notch. Are there issues? Most definitely, and I myself have done an exchange for a second set and have realized that the holy grail of a "perfect set" is almost non existent. Having said that, at the end of the day, the only question should be, "Are you happy and satisfied with how content is displayed?". I revel watching HD and 3-D content with this set and would not have chosen any other LCD at this time.
As for settings, after trying everyone's settings from Rizzo and Dennis, I have come to the conclusion (entirely subjective) that less is more. I have disabled nearly all settings, and like bareby, gone with a more natural look. Also, for the longest time, I went with Warm2 and had gotten used to it, but having just purchased LOTR BD, for those that own it, the transfer has a greenish tint on some scenes and combined with the Warm2's slightly orange tint, I felt it really did not do the series justice. So it has convinced me to use Warm1 while pushing Color to 60, to give a brighter and slightly cooler (more blue) look and as a result, it has really changed a lot of the content I watch. The only other setting I give preference to is RC, which I set to 20-25 and min on noise. I find it gives that extra layer of clarity to web streaming content and a lot of my 720p movies I stream using DLNA. It even helps BD, as sharp as the image is already.