Turn off Dynamic Contrast Ratio.
Turn off Ambient Light Sensor.
Turn off Noise Reduction.
Turn off White Level limiter.
Turn off Black Level Extender.
Then get yourself a calibration disc like Disney Wow or AVS 709 or Avia and set the Backlight down to under 50 and set Brightness (black level) and Contrast Ratio (white level) according to the tests. Then bump the Brighness down a couple of notches and the Contrast Ratio up a couple of notches. Then punch up the Color saturation a couple of notches.
Then check out the picture with Adaptive Luma turned on and off, to see if you like it. Also try turning the Smart Motion Flow or whatever Vizio is calling it, on and off and at different levels to see which you like best. I say turn this on off unless you are watching sports.
Panasonic AX-200u / Optoma Graywolf 92" / Draper Luma 92"
Samsung 51F8500 Plasma / Vizio M422i LCD / Vizio GV42LF LCD / Vizio VP322 Plasma
Sony S790 BD / Panasonic BDT220 BD / Roku 2 XS & HD-XR / PlayStation 3
Oppo 983H Anchor Bay VRS / Denon 2930CI Silicon Optix Reon / Panasonic S97 Faroudja Genesis / Oppo 970HD Mediatek
Panasonic LX-900 Laserdisc / Aiwa MX100 Multi-region VCR / JVC S7600 S-VHS