So far with my 52XBR4 I just went to Custom, bumped the color up to 55, put the sharpness to 50, DRC off, I set everything else in advanced settings to low except MPEG noise reduction & clear white are both off, color space is set to wide. Motion flow is off, except for sports, Cinemotion is off, color temp is either neutral or warm1 depending on my mood. This seems to be a good jack of all trades settings for my SA 8300HD via HDMI. Hopefully I'll be able to fine tune it more as time goes on but for now I'm very happy with it. When I have more time I'll list all the settings but that pretty much sums it up.
Edit - this is no longer accurate, I posted my current settings later on in this thread.