It should work just fine. I just got a Harmony 1000 that so far is stellar. The number of products it supports is truly astounding.
Television: Mitsubishi WD65737 DLP
Processor: Emotiva UMC-200
Amps: Carver AV 806x/Behringer EP4000
Mains: DCM TimeFrame 600 Center: AT 453C
Surrounds: AT 251.1 Sub: Danley DTS-10
Blu Ray: Panasonic DMP-BD655