I'm struggling with the decision between the 401b and the 2200 myself and would love additional input.
First, let me admit that you probably won't believe what I'm considering 'downgrading' from. I have Definitive Technology BP2002 towers with dual 10" powered subs and a Boston Acoustics Center Channel, and in-ceiling BA rear speakers, driven by a Pioneer 7.1 Dolby Digital Receiver.
Why switch? The towers are huge, and I'm replacing my 60" Sony SXRD with a true flat-screen, and want something that looks much neater in the room. Also, I don't find myself listening to movies or TV with a discerning ear - we struggle to find a volume level that will make dialogue clear but not blast the house with sound effects. Having heard the YSP1100 in a small room, I was very impressed with it's ability to fill the room and hold clear dialogue at any volume.
The 'high-end' side of me thinks the YSP-2200 is the easier and cooler choice. BUT, the room is fairly large and I worry about whether it can keep up and create even the sense of surround (I don't expect full surround, just crisp, rich and room filling effects). The 401b, on the other hand, seems weak and small, BUT has outputs for rear speakers so I could connect the in-ceiling units and retain 'true' surround. What's that worth if the front is going to seem so weak compared to what I have now?
Most of the audio emanates from the center channel in my current config, until effects/music kick in and then the BP2002's over-power the room. Seems like the 2200 would be nice for providing a similar/better dialogue, but the 401b would be better for surround.