I use this remote with my main Windows Media Center setup. The mouse controls are a little slow, but that's ok for me. I only use the mouse controls for emergency issues. There is a button at the bottom called "close" which will close the current open window/application which is real handy if you use multiple applications or front ends on the system.
The two things I don't like about that remote is the play button will also pause. In Windows Media Center, with most other remotes I have used, if you hit the play button while something is playing you will get the timeline bar at the bottom of the screen and the time in the corner. It's just a habit we have gotten used to. With this remote, the play button also pauses what is playing. It's a minor inconvenience.
The other thing I don't like is a little more annoying... the numbered buttons do not have any letters... so you can't use them in Media Center to search in a text-message type way. For instance, you can't hit the number 6 button to get to the "N"s in your list of items or when trying to search for something.
Other than that it functions really well and is pretty cheap.