I have two Nexus players, but neither are hooked to a receiver so I don't know if they will play lossless audio. The main thing about the Nexus is it is wifi only, and I have found that even on a very good wifi connection, high bit rate movies will skip/stutter if you don't tell the Plex server to transcode them at least a little. So, that means that even if it could play lossless audio, it's probably out of the question on wifi. And, trying over half a dozen wired USB ethernet adapters, all resulted in very poor performance, much worse than over wifi. For the record, I'm running Ubiquiti AC Pro access points (dual band), so I have just about as good as it gets when it comes to wifi (Ubiquiti is/has releasing/released one that handles more users).