The main thing I was trying to do was move my MySQL database which I use with XBMC and my thumbnails folder (with all my poster, fanart, etc.) to an SSD. I ended up just adding the SSD as a secondary drive and adding them that way. I have seen a noticeable improvement on my XBMC clients now.
Also, occasionally I have to reboot my server after making changes and whatnot, and it takes forever to boot back up, probably 20-25 minutes. It's not really a big deal though because I do it rarely.