Well, the absolute highest quality settings are rip and re-mux where you don't re-encode at all, but your rips (I use MKV) will be big; 15-30GB depending on the movie. To get that down to <10GB, your going to have to experiment. If your happy with re-encoding to 720P, that will keep the file size much lower, but otherwise if you want to keep the rips as 1080P, I tend to leave all the Handbrake settings at the default, and just tweak the RF setting on the Video tab. The default (20) generally does a good job, but reducing that (10-15) will generally increase the quality (and filesize). I'd try 15 first, and see where that get's you. Just remember, it can take 2-3 hours per movie to re-encode, even with a quad core.