My "HTPC" is also used for gaming, browsing, work etc. rather than only media functions, so I have a wired keyboard & mouse setup.
I use a Happy Hacking Keyboard Pro 2 Type S, because I like Topre keyswitches better than anything else. Since switching to it after trying scissor-switch keyboards (Logitech) and a few Cherry MX keyboards, the pain in my fingers from typing all day has disappeared.
I use a Razer Deathadder 2013 for similar reasons - nothing fits my hand better, and the force of the switches is just right. With other mice - particularly logitech - the force is too high and I have pain in my index finger at the end of the day.
I keep a Logitech Anywhere MX mouse hooked up too, because not being tethered is sometimes useful, and it will track on just about anything - but I do notice a slight lag from it being wireless (never found a wireless mouse I didn't notice at least a frame of lag with) and every time it is "active" I hear a high-pitched whine coming from it. (no-one else seems to hear this - but I have this problem with a lot of electronics) I've had both revisions of this mouse, and the newer one is better. The scroll wheel is awful though, just like any dual-mode wheel from Logitech, or a tilt-able wheel from anyone. I would prefer it if it was ambidextrous rather than a right-handed mouse too. Still, I haven't found a better mobile mouse. (the Razer Orochi seems better on paper, but I don't like it for a number of reasons) While it may not have the "convenience" of Bluetooth and requires a dongle, I've never found bluetooth to be reliable, so that's actually a good thing in my opinion.