Sorry, but there are many ways to accomplish your goal, and everyone, including myself, is going to give you slightly different advice. So you have to weigh the options and decide for yourself what is best. Personally, I want the best picture quality, lowest cost, and most ease of use. I'm with Adam on using WMC and Extenders for cable TV DVR functions and Roku or BD player or Chromecast for Netflix, Hulu, etc. And if you have any smart TVs, use their built-in streaming apps. Otherwise you're looking at more complexity and expense and lower picture quality. I wish there were a good, all-in-one solution, but there isn't yet. There may be soon, if Ceton gets its act together with the Echo, but that hasn't happened yet.
A simple universal remote in each room can integrate everything quite nicely. Just program it so you press the TV button to watch TV, press the Netflix button to what Netflix, and so on. That's very simple for anyone to use, and the actual device doing the streaming doesn't matter. So full WMC integration of everything isn't necessary.