I don't have a dedicated room as you know, but the relationship between equipment and room is important. One of the reasons I like bipolar speakers (which mine are) is that reflections can be an asset rather than a liability. There's more flexibility of placement. With conventional speakers you'll need to be more mindful of placement and of reflections, I think. If the equipment tends toward the bright side, then the panels and room treatments will become more important. Those more accomplished than I on these things can weigh in of course, but considering the treatments as part of the system (the room certainly is) may be a good idea. Maybe start with the acoustic characteristics of the room itself, before anything's put in there, and work from that.
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