I'm wiring my brother-in-law's new home for distributed audio and video. I used to work in the industry (8 years ago) and am out of touch with the current offerings. Here's a brief run down of the configuration:
12 rooms with home-runs for a pair of in-walls or in-ceilings
Four rooms with dual CAT6, RG6QS home-run drops for HDTV
One "theater" space with home-runs for two on-wall HDTV locations, in-wall/in-ceiling surround, dual subs.
My sister-in-law uses iTunes and Satellite radio for audio. She already uses a few Airplay speakers. So, it would make the most sense to go iPad/iPod touch for controllers. That said, I think I should add control pad CAT6 drops to each room wired for speakers.
Who has a multi-room audio setup using Airplay? What about the theater? Just use CAT6 baluns for HDMI and control? Ask away.