I generally use high profile, slow encode, constant quality 16 for DVDs. Blu-Rays are the same, except quality 18-20 (sometimes 21). Lately, I've started experimenting with the Plex Optimizer. I keep the 1:1 rip from MakeMKV and then use the Optimizer to create a second file at ~12Mbps.
Main System: Sony XBR75X940C * Onkyo TX-SR805 * Marantz MM-9000 * MSI Cubi Plex Media Player * Samsung Blu-Ray * Roku 3 * Squeezebox * Paradigm Studio/40 v.2 * Paradigm Studio/CC v.2 * Paradigm ADP-370 * SVS PB12-Plus/2