It will work with any MoCA compliant router/modem. The ECB2200V isn't a device that will work on it's own though. If you don't have a router/modem with MoCA enabled you would need a ECB2500 or similar device to connect to the router/modem and bridge the coax network to the ethernet network.
The ECB2500 also comes in a two pack to connect one to the router/modem and one to a switch or device at the other end. http://www.amazon.com/Actiontec-Ethernet-Adapter-Service-ECB2500C/dp/B008C1JC4O/ref=pd_sim_e_3
Running Windows Home Server 2011 Evil Abandoned Edition