I just watched this for the first time. One thing that bothered me is that Spider-Man seemed like a total weakling when battling the Lizard. Maybe the Lizard is significantly stronger than Spider-Man, but Spider-Man is super strong himself, and I would at least expect him to get a few good licks in, instead, he seemed like an acrobatic weakling almost powerless against the Lizard. And in the climax, it was more Capt. Stacey who was kicking the Lizard's a## than Spider-Man, which made Spider-Man look even weaker.
All in all, I enjoyed the film, but was somewhat disappointed by it. I like Garfield more than Tobey McGuire in the role; although Tobey's portrayal had its good points, he was too much of a dork nerd, compared to Garfield, who is more of cool nerd, and Tobey McGuire couldn't tell a joke to save his life, which didn't word for the wisecracking Spider-Man. But overall, I thought Spider-Man 1 and 2 were better done movies, though this was better than Spider-Man 3.