From what I've heard, my biggest problem would be multipath related, if I have problems. I live in the city, apparently near the towers. We don't have much on the air yet though... the CBS station, a low-power UPN that may be too far away (about 40 miles) for now at its power level, and that may be it for New Orleans at this point in time. I think a couple more are expected to be broadcasting soon though.
I'd give my right arm to be ambidextrous.