I dont' think it will be a problem. Get a real good set of front L/R 2 channel speakers and a great sub..Your room, while accommodating, is not too large for most towers to make great sound. A decent tower set up for fronts will take you very far (and depending on choice, may or may not need sub from the get go, but you'll likely add it later for movies. Music should be fine, maybe even preferred, on 2 channels. You may also want a decent receiver to power it all up (avoid the lowest cost options)
I am in similar situation with a similar size room. After having listened to 15+ speakers, my top 4 are PSB Synchrony Two, Dynaudio X32, Dynaudio Focus 220 and Totem Hawk. Also of interest are the Ascend Sierra Towers and Salk Song Towers. In addition to these, there are plenty other great options, but neither of these should disappoint, even in the space you are considering.