The main concern will be how to place them to not end up with a comb-filtering machine. Vertical with the top cab inverted is best, horizontal with the cabs on their sides placing the tweeters as close together as possible may suffice. Series wiring them to 16 ohms will give low sensitivity, they may not keep up with the mains. Your amp appears OK with 4 ohms anyway.
Bill Fitzmaurice Loudspeaker Design
The Laws of Physics aren't swayed by opinion.