For most comfortable and best sound, I have taken these with me on airplanes, music even low volume will keep you from hearing noise, have had them going on 8 years and still the best headphones I have. What they don't say is that These are very durable much of it is made of metal, the ear padding is easily replaceable too.
Take a look at Sony Mdr-7506
For more isolation, feels more like wearing shooting ear muffs, I use the when playing drums. Definitely more isolation than Sony, I bought them for that reason. These are made mostly of plastic, I broke one of the head bands though it was easily replaced, this was a common problem, not sure if they have fixed yet.
Direct sound extreme isolation ex-29
These are the most portable, least obtrusive, and most isolating when worn properly. They are probably a better fit for you. I am not a fan of ear buds as i can't get them to fit right. they may have better sound than the mdr-7506 though i doubt it. Still most people report great sound. They have a replaceable cable which uses a small socket joint/connection which you might have to be careful/gentle with. Shure se215
Note, all of these are designed as monitors for semi-pro to pro musicians. Their sound quality will likely be hard to beat.
Also over the ear, circumaural will isolate better than on ear headphones.
I would stay away from noise-canceling as it introduces noise and artifacts. My friends, coworkers and I can hear them.
All of the above come with a carry bag, and are designed to fold up or collapse, except the se-215 which can more easily be coiled up. The se-215 in ear monitors also come with different sized and type fittings.
Depending if your an audiophile both the Sony 7506 and ex-29 come with a threaded gold plated adapter, for what it's worth.
There are some ideas, hope it helps.