I'll occaisionally have fun with some of the sound programs, mostly Cellar Club; but for music I almost always come back to 7 channel stereo. I like the room filling effect. Pure Direct is nice too, but lacks the punch of 7ch stereo, so I usually go back. Also, sometimes I use the sound programs to make up for poor recordings, dead mixed can be livened up a bit.
That's for music, for movies I always stick with Standard.