Certainly less than ideal -- I don't think you'll find many with experience in doing that. You don't mention what kind of pre-pro/AV receiver you are running, but if it has RoomEQ it may be able to compensate a little...but I'd guess that your sound stage will collapse to the side that the center is biased and RoomEQ may mitigate but probably not solve it.
Basically, I wouldn't do it unless you can stick it underneath the TV in between the two...and, of course, most people can't because they don't want the TV that high, which is why this is an arrangement typically reserved for AT screens, people who don't mind hurting their neck, or people whose seating position cuts down the viewing angle enough to make it acceptable. Of course, you can change your seating (recline/raise it) to help with the viewing angle, but then it's possible the tweeters wind up firing over (reclined) or under (sitting up higher) your head to compensate for the TV height, which is probably even worse, but I suppose solvable by tilting the speakers.
Basically, I wouldn't do it. But, if you do, make sure you can return it and try out the center if things don't work out. IMO, there's a high probability they won't.