Just got a Harmony 1100 a couple days ago. So far so good. I went from a 880 to a One and now to the 1100. The One was much better than the 880, but the One and 1100 are comparable depending on your preferences. I definitely had to get used to the touchscreen and having to look at the screen when I need to select something that was not one of the hard buttons. I will miss my One but a couple more weeks with the 1100, the feeling should pass.
I also got the RF extender; it is en route. The harmony 1100 is a beautiful remote. The matte finish gives it a very nice look without over doing it with a shiny finish. The One has the shiny finish but that went well with the contour and shape of that remote and with the 1100, that would have been too much.
I never used sequences, therefore I don't have an opinion on it, but the concept seems pretty ideal for certain situations. The battery life (when it is not docked/charging) was ok but could be better. The touchscreen was ok (QVGA) but should have been upgraded to a VGA screen but on the other hand you are NOT buying the remote to look at the screen all day. The angled charging base is a nice new look compared to the "flatbed" look of the 8xx, 900 and One.
Updating the remote is much faster than it was on the 880 and the One. The layout of the customizable buttons is very appealing. I am sure some people would like to be able to more buttons and icons around, although I wish we could customize the icons.
My 2 cents on the Harmony 1100.