I also have that vizio soundbar, which spurred me to get the harmony 650 to control everything with one remote. After a couple weeks I couldn't stand the harmony constantly losing its programming. The customer service people tried, but honestly some of them could barely speak english and it was very irritating to hear them continually telling me to check the battery connections (shouldn't that just work anyways?) and re sync the remote when it obviously had a deeper issue.
In summary, returning my harmony 650 and getting the URC R50 was a great decision. The R50 is not that difficult to program, and best of all, it consistently works!