No LCD, no backlight and only four devices ... and only one activity.
The "Watch TV" button is the only one that is an activity; it turns on your cable box and TV and switches it to the right input. The four buttons we would normally associate with an "activity" on a Harmony remote ... the TV, DVD, Cable/Sat and VCR/aux buttons ... are "mode" buttons to switch the remote over to control that device.
So instead of pressing DVD to switch the TV input, turn off all other devices, turn on the DVD player and switch the remote to controlling the DVD player, you probably press TV, Input (however many times to get to the right input), DVD, Power and you're ready to go.
More is explained on the quick start guide in this PDF file
I don't know if you can program macros to the "programmable buttons" or if they are simply one-code buttons like the rest of the buttons. Looks like they are "one code" buttons to me.
I'll probably get one; I can't get my family to use my "scary" 880. Even the 650 causes them to screw up their faces .... I think they are afraid of the LCD screen. Maybe there will be a 350 model with four activity based buttons.
This does have a few things going for it: it uses AA batteries (the entire remote is only $10 more than the last battery I bought for my 880). Without a display screen the batteries should last a year or more. The "mode" or device-based model of button pushing is more familiar, almost identical to our Dish Network remote, so the learning curve is a lot shorter.
I looked for one in Fry's and Best Buy today, but they aren't on the shelf yet near me. I may order one from Amazon.