Just purchased Roomie and an iTach, and I'm loving this thing. So far, all my home theater and family room devices are supported, about half via IP control - coming from two slow and laborious-to-program Harmony 1100's, the Roomie removes a major, loathsome burden from the process of programming.
TiVo Premiere XL
Sharp 70 LCD ( forgot the exact model at the moment)
Sony vpl-VW 1000
Mac Mini (iTunes)
Octava 4x4 HDMI Matrix
A few remotes are a little generic, but nothing deal-breaking
The trickiest thing will be managing multiple rooms on multiple devices - while they offer iCloud sync, this is not practical as I can't share my log on to my wife and kids' iOS devices. With backups, they are not device specific, so as best as I can tell, you have to take are not to program on two different devices lest your configs diverge - best to program all rooms from a master device, backup to Dropbox, and then restore to the slave devices as needed. A little more robustness in multi-room, multi-iOS device backup or syncing would be nice...
But really very pleased with the overall solution...