Day 2 with my MX-780. So far no issues whatsoever. Still grabbing the dedicated remotes when doing complex programming or settings work on a specific device, but for everyday remote control needs this is perfect. My system is modest, currently only a main zone 5.1 setup with Samsung LCD, Directv, Apple TV, Anthem MRX-500, Panny 3D Blu-Ray, Linn Mimik CD transport.
McIntosh MX121. McIntosh MC205. Focal Aria 948 Main Speakers, Aria CC900 Center. Focal Electra IC 1002 In-Ceiling Surrounds. Paradigm Studio Sub 15. Oppo BDP-105D. Roku XS. Roku 3. Apple TV(3). "Silenzio" EA-2 Media Server (pc-based). DirecTV. Panasonic TC-P65VT50. Samsung UN40FH6030F, URC MX-780.
My current SACD list