Since you will be moving a lot, definitely a good idea to go with bookshelves and a good sub. The SB-2000 can definitely do a great job with the lower frequencies, negating the need for larger tower speakers.
However, that's a REALLY big space. Is that all one big open room? If so, it would take a lot of sub to work well there.
I have heard good things about those Pioneers, but don't know much about them.