OK I resisted it for to long, I finally got a Harmony. I have a MX500 for my main system front projection/stuff/even more stuff/and stuff/and whatever stuff system. I just thought I would never get used to Activities based remote usage. Well upstairs where we watch talking heads, listen to CDs, radio and other stuff, I thought for that system why not.
We were at Best Buys not so secret sale last night, for reward zone participants. And they had the 550 for $59, it was between the 550 and a URC inc. learning remote for $20 at best buy last night, and I am so glad I got the Harmony. Even my mother could run my living room system, now, and that is saying A LOT. Where we had two or three remotes (cause not one of the remotes could do all that we needed), for 6 things, we now have the 550 to do all things.
Only one problem, once you have gone Harmony you are going to need a Harmony in all your systems, I guess I will have to sell my URC inc. MX500 and get another 550 for the "big system". Although a color screen looks cool...might have to move up the Harmony chain for that system.