I have mixed feelings about it.
Well, to get off on a good note, let me first say that I expected a lot worse based upon the comments of those who had seen the pilot in advance. Unfortunately, that's one of the few good notes I can offer until further episodes become available.
What I didn't like (in no particular order):
The blonde definitely still has to go. Her acting was more unbelievable than anything else in the whole program. I didn't believe her as a fed, as a scientist, or as a woman in love. I
did however believe her as someone who could probably find her mark on a stage, with the help of an infatuated drama coach.

And to make matters worse, you strip a good-looking blonde down to her black bra and panties, and normally you've got my undivided attention for awile. I couldn't believe she was almost as boring half-nude, as she was fully dressed. I had been hoping for something with a little more sex appeal than Ovaltine.
I know there are a few here that like her, and I can only conclude that perhaps something about her that reminds them of a high school teacher or college professor that they used to have sex fantasies about.
Mark Valley - Okay, but no better. I always considered him to be a smarmy version of Joel Gretsch , although Gretsch tended to be more believable. Maybe they should have used Valley & Gretsch as the Siegert twins

Oh, and speaking of Valley, making him look like Heath Ledger's Joker after the car accident took place towards the end, did little to help the show's cred.
Lance Reddick - As a mysterious and enigmatic figure on LOST, he's great. As a stuffed shirt G-Man, nowhere near as interesting. He seemed to lose some juice without the menacing style.
The overuse of the 3D letters indicating the location struck me as a Hey mom, look what I did moment.
LSD as a panacea or mode of enhanced communication? Lots of theories floating around about this while I was living in Boston during the late 60's - early 70's, but it never really panned out. You know its got to be Fox when drug use is being encouraged, no matter how surrepticiously.
What I did like: (thought I'd never get here, huh?

) The Scientist. He was the only one on board who didn't come across as a cardboard cut-out. character. And his eccentricities provided what little comedy relief that could be found. How come USA is the only network where someone remembers it is the characters (and not the leads) who usually make or break a show?
The Siegert Bros. : On a personal level, I've always been fascinated by the psychological aspects of identical twins. I hope this is explored further and doesn't degrade into a simple cloning scenario.
I heartily agree with all those who share X-file concerns, but I'm willing to give this show another couple of eps to remedy its growing pains without appearing like the obvious X-files/Millenium cross-over that others have observed.
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Palladin
Chance favors the prepared mind