This is an interesting question, and one I have been wondering about myself.
Cable with RCA connectors is shielded cable. I would rather not solder an RCA connector to a paired (unshielded) wire. Nor would I want to strip RCA shielded wire and twist the shielded side for the negative and the core for the positive.
I have about 50 ft of good quality 14 ga. speaker wire running in my walls for back surrounds, which is paired (unshielded) regular speaker wire. I would like to use one of these to experiment with sub placement using the LFE connection from my receiver. I read somewhere that Radio Shack sells banana clip to RCA jumpers, but this isn't something I have ever looked for, so I'm not sure they exist. I see two problems:
1. lack of shielding, which might cause hum.
2. Too much resistance. What does 50 ft. of 14 ga. wire do to the LFE signal?
I suspect neither of these would be a major problem, especially the lack of shielding on the wire in the wall. And to the second concern, 50 ft. of 14 ga. wire would produce a negligible resistive load, but such a heavy gauge, copper wire is also highly conductive (efficient).
Those who have experience with this, please tell me if I'm wrong.