Take Me Home.
http://www.imdb.com/title/tt1261954/combined
Netflix recommended this under the heading "Quirky Road Trip Movies." It is a road picture and a comedy that happens to be a romantic tale (I don't think it's fair to tag it as a "rom-com," because that implies it follows a chick flick Hollywood formula). It is independent and was written and directed by one of its stars, Sam Jaeger. If you recognize his name from TV's "Parenthood," it's because it's the same dude (never watched it myself).
It has many of the conventions of a classic road trip picture, and some of the conventions of a romantic comedy, but because it's not a Hollywood film it has a lot more room to breathe and be more authentic than a big money formulaic film. It actually has heart, excellent acting, some authentic moments, and some excellent cinematography. Above all, the chemistry between the leads is real and palpable. Upon seeing the end credits I realized why. The leads are real life husband and wife, and their comfort with and love for each other is evident on screen. This movie works and will put a smile on your face -- a genuine smile, not the Hollywood kind.