As have others I got my Harmony One to work instead of the Dell Media remote by having the Harmony SW match up the remote and it ended up as a "Medion EPC II" device. All the functions did work but a few buttons had to be learned. The last thing I wanted to set up with my Harmony One is the Favorite Channels, for the USB HD TV tuner I have working within the Media Center. After the remote was set up I tried it and was suprised to see that the Harmony was sending out the commands for the TV's buttons which threw the TV out of the HDMI input for the Zino and into its built-in tuner to tune the channels.
To make a long story short, the Harmony SW does not think that the "Medion EPC II" device can tune channels, so the only buttons it can send are from the TV. There is a solution though! I saw on a post on another forum that you should make the Dell remote a Windows Media Center device under Computers, Microsoft, Media PCs. This way it knows that it can tune channels. So when you set up the activity for the Zino, you need to say that the channels are changed by the Windows Media Center device.
BUT . . . there's one more gottcha! For some reason the IR codes from Harmony for the Windows Media Center device do NOT match up with the Dell remote and thus don't work! The solution is to just learn all of the buttons from the Dell remote into that device. It really doesn't take too long and after that everything works, including favorite channel changing. I have no idea why the Dell remote did not match up with the Windows Media Center device IR codes as I would have thought the Dell remote was a standard Win Media Center remote. But as long as it works it was no big deal!!
P. S. When you learn the Dell buttons, the one marked as ".*" must be labeled as "." so that it will match up properly when you set up a favorite channel such as "8.1".