Recommendation is to "age" the panel for a good 150 hours - some like 100, others up to 250 - we saw changes in our 60ST50 out to at least 400 hours.
Personally, would get a copy of the AVS HD 709 disk, or one of the commercial alternatives (Disney WOW tends to get good reviews), and adjust YOUR set to suit YOUR eyes / viewing preferences.
Still, there have been a number of Recommended Settings posted on various sites - including this one, and these can make a good starting point. Try a search.
From memory, the settings posted with CNet's review of the ST50 were very close to those recommended by D-Nice for a non-aged panel.
We basically used Default Cinema or Custom depending upon source (with only minor changes) until our normal aging routine was "complete," and then used the AVS disk to adjust the panel - and still ended up with only minor changes from default Cinema for blu-rays.
One of these days, plan to get around to trying the DVE program with its fancy filters (have borrowed eldest son's copy), but PQ is so good that there hasn't been a lot of incentive to spend the time...
Enjoy your new set!