New Hard Drive won't initialize.... "the device is not ready"

i have a new WD 2TB hard drive that I'm putting into a MediaSonic USB3.0 external enclosure. After attaching the hard drive, I went into Computer Management to initialize the disk. When I tried to do that, I get an error that pops up from the Virtual Disk Manager that says, "The device is not ready".

I've tried detaching and re-attaching the drive and rebooting my HTPC, but no luck.... Any ideas? Do I have to initialize it with a SATA cable on the motherboard first before putting it in the enclosure?

Thanks.

I attached the hard drive to my motherboard and it initialized fine. And then I put it back into the enclosure and everything was ok. Not sure what the deal was last night....

Yes, I do have USB3.0 on my mobo and I'm using the cable that came with the enclosure.

I tried a couple of transfers.... when transferring mp3s and photos I was getting around 50 MBps. when transferring home movies (Canon .m2ts files), I was getting around 68 MBps.

I haven't tried updating drivers or anything... I did see a bunch of sticky posts on the MediaSonic forums about updating drivers.