This should be interesting: I've never owned a universal remote, and the individual remotes for my delightful hodge-podge are beginning to fail. I've read the thread and done some research. It looks like the HSC wins and will be in my very near future.
I'm delighted to see the factory here, and have made a cheat sheet of all the potentially relevant tips other owners have brought up to try and minimize the culture shock!
Pricepoint, the replaceable battery in the remote, and ongoing, responsive software updates to the system closed the deal.
It is fascinating to see LG's Optimus G is trying to make an entrance to this market.
I'll post my experiences here as they arise.
Thanks so much to the Harmony folks for their earnest and professional presence here!