It makes about as much engineering sense as putting a snow tire on one wheel of your car, a rain tire on another, a summer tire on the third and a racing slick on the fourth. The intent would be to have good performance in all road conditions, the result would be bad performance in any.
Utterly inappropriate example strictly speaking in the context of two sub boxes both serving different pass bands and used within the same room. I did it a couple of years ago. One box (10" driver) was playing frequencies from 80Hz to 50Hz and another (12" Driver) playing 50Hz and below. I did that coz the right side of my room was offering great depth but very ruffled up upper bass; while the left side offered completely opposite. Hence the need for two separate boxes serving different pass bands.
Somewhat the same thing is very much possible within one enclosure housing two different size drivers in their own completely isolated enclosures within the same box. One can use an iNuke DSP amp for splitting the bands at DSP level and employ two channels of iNuke to serve separate compartments within the same box. One can be assigned to play upper bass while the other can handle the ULF.
Not a big deal.