Zappiti, Yadis, 10Muse, My Movies are some of the programs you can use for jukebox purposes. I used to use Zappiti, which is probably the easiest jukebox to use, and the most simple. Yadis looks a much nicer and skins are free. I am currently using 10Muse + iPad App.
If you do a little bit more research you can find a lot of information such as http://www.mediasmartserver.net/2010/08/13/guide-setting-up-zappiti-for-the-dune/
This is an older guide, but its pretty much the same set up for the new Zappiti.